PKRRATING NO FURTHER A MYSTERY

The interfacial residues are hugely conserved among eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements show which the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations aid a model in which activating RNA serves as being a scaffold to bind multiple PKR monomers, escalating the

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